dMMR mCRC
1L Ipi-Nivo VS Chemo+biol
303 pts
2y PFS 72% VS 14% HR0.21 P<0.001
(What about the 3rd arm – Nino monotherapy?)
dMMR locally advanced colon
Neoadjuvant Ipi (x1) Nivo (X2) à surgery
108 pts
Major path response 90% Pcr 68%
3 y DFS 100%
Rapid ctDNA clearance
(Maybe no need for surgery?)
mCRC unresectable liver mets only
Systemic treatment à liver transplant
94 pts, chemo responders, age<65 CEA<80, no BRAF mut
5y OS 57% (vs 13% in non transplant) HR 0.37
(is liver transplant SOC based on 94 pts non randomized single country trial?)
GEJ
Neoadjuvant FLOT VS CROSS
438 pts, 80% LN+
3y OS 58% VS 50% HR 0.7
pCR 17% vs 10%
(No adj Nivo in CROSS arm)
HCC advanced
1L Ipi+Nivo VS TKI (Lenva 85% Soraf 15%)
668 pts
ORR 36% (7% CR) VS 13%
Med OS 23.7 VS 20.6 mo
(OS on TKI 1L>20mo?)
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